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Mechano-genomic regulation of coronaviruses and its interplay with ageing

Identifieur interne : 000487 ( 2020/Analysis ); précédent : 000486; suivant : 000488

Mechano-genomic regulation of coronaviruses and its interplay with ageing

Auteurs : Caroline Uhler [Suisse] ; G. V. Shivashankar [Suisse]

Source :

RBID : PMC:7115351

Abstract

Coronaviruses employ various nuclear signalling mechanisms for their propagation. Here we link replication of coronaviruses, including SARS-CoV-2, the coronavirus disease 2019 (COVID-19)-causing virus, with cytoskeleton-dependent signalling and 3D genome organization. This link could provide novel insights into the high coronavirus pathogenicity in certain cellular states, particularly those associated with ageing.


Url:
DOI: 10.1038/s41580-020-0242-z
PubMed: 31676888
PubMed Central: 7115351


Affiliations:


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PMC:7115351

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{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    2020
   |étape=   Analysis
   |type=    RBID
   |clé=     PMC:7115351
   |texte=   Mechano-genomic regulation of coronaviruses and its interplay with ageing
}}

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